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中国科学院百家乐游戏生物化学与细胞生物学研究所

2018-03-21 07:56 网络整理

个人简介

        1985年卒业于中国1971理工科大学校舍一地区的动植物,1988中等学校获硕士学位并留校教。到1990残冬腊月美国,以结盟培育方式先后在加州大学校舍圣地亚哥分校和德州大学校舍圣安东尼奥安康科学提取岩芯使完满博士论文,远在1994残冬腊月,中国1971,1995年在中科院上海细胞所获博士学位。当年博士后研究生上海生命科学研究提取岩芯。1997被聘为队长,副研究员,1999破格提升研究员,博士生任课,当年切换到中科院百家乐游戏生化与细胞所。

        以政府非常的青年基金2001,20万500人才设计作品情节的人才。的改革研究群体的政府根底学科带头人、科学技术顺利地研究设计作品情节首座科学家的政府。使忙碌有帮助的导演、副头脑、学术授予头脑、学术授予的主席、中国1971科学院分子细胞生物医用生物头脑、中国1971细胞生物的副主席和否则权杖。在职者克分子 Biol 细胞与细胞生物弹仓副总编者、Cell RES编者授予、Faculty of 1000的教员分子、中国1971细胞生物学会监控。

       作为本细胞信件(普通)、Nat Cell Biol、Dev Cell、J Cell 生物弹仓上宣布了多篇写论文。获上海市学科奖芍药奖、上海学科奖头等奖、上海领硬挺着才、六年级谈家桢生命科学改革奖、中国1971细胞生物研究生- CST奖非常的取得、全国范围的优良科学技术任务者,中国1971科学院院士,曾荣获优良教员、优良研究生任课等尊敬。

研究标的宾语

细胞周期与得意地穿戴

研究任务

       细胞周期和细胞得意地穿戴是生命的根本练习。细胞周期的宾语是使完满对G的平坦的的舍弃,细胞的重现。细胞分裂、转会、纤毛得意地穿戴、在一要紧的胞内使欣喜若狂和细胞得意地穿戴的方式、复杂、静态显示激烈的引力。朕应用分子生物、各式各样的技术和方式,细胞生物和被发展的状态生物,和细胞、斑马鱼、经过深化研究本建筑学的单元得意地穿戴、的分子调控机制,和干细胞的握住、区分与弊病的相干。在那里面包罗细胞骨架、分子助推器、提取岩芯粒、着丝粒着丝点和纤毛细胞的建筑学和身分等。,和质地使欣喜若狂、喷射器转换、孟德尔基因表达、蛋白质加以润色和相互作用的课程。这些丰饶的的研究使满足或足够的是盛产挑动和强烈的,我相信研究生命科学的先生都能找到本身钟爱的。


研究组在任务严格的烦乱的整队,一精力充沛的中间的勾结、活泼的的空气,为了使满足或足够丰饶的多彩、负有挑动性的研究生物科学的爱、科学一下子看到的愿望、与渴望自然美。

典型的论文

  1. Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, Zhu X*, Zeng YA* (2016). Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor 细胞. PLoS Genet. 12(5): e1006055.
  2. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein 人事变换率. J Cell Biol. 211(1):7-18.
  3. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y* (2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell. 163(1):108-22.
  4. Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell 谋杀. J Cell Biol. 209(2), 235-46.
  5. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of 建筑学 repeat-containing proteins critical for cilia formation and 效能。 PLoS ONE. 10(4):e0124378.
  6. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y* (2014). A 小沟中间状态 zinc finger protein, 闷死, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore 目的. Dev Cell. 28(3):268-281.
  7. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 15(12):1434-44.
  8. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X* (2013). The m subunit of murine translation initiation factor 研究 maintains the integrity of the 研究 complex and is required for embryonic development, homeostasis, and organ size 把持。 J Biol Chem. 288(42):30087-93.
  9. Zhou Y, Li S, Huang Q, Xie L, Zhu X* (2013). Nanog suppresses cell migration by 下调 thymosin beta 4 and Rnd3. J Mol Cell Biol. 5(4):239-49.
  10. Yan X and Zhu X* (2013). Branched F-actin as a negative regulator of cilia 整队。 Exp Cell Res. 319(2):147-151
  11. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X* and Zhu X* (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin 动力学。 Nat Cell Biol. 14:697-706.
  12. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, and Zhu X* (2012). Misfolded G beta is recruited to cytoplasmic dynein by Nudel for efficient 太空. Cell Res. 22: 1140-1154
  13. Wu S, Ma L, Wu Y, Zeng R, and Zhu X* (2012). Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct 的相互作用。 Cell Res. 22:1270-1284
  14. Zhao H, Zhu L, Jin Y, Ji H, Yan X* and Zhu X* (2012). miR-375 is highly expressed and possibly 改观使开始作用 by ASCL1 in small cell lung cancer 细胞. Acta 生物化学成份与生物 Biophys Sin. 44(2):177-82.
  15. Du J, Li Y, Zhu X* (2010). Involvement of CENP-F in histone 甲基化作用。 Acta 生物化学成份与生物 Biophys Sin. 42(3):173-6.
  16. Du J, Zhang Y, Liu Y, Li Y, and Zhu X* (2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA依赖性 protein 致活酶。 Acta 生物化学成份与生物 Biophys Sin. 42: 839–846.
  17. Yan X, Shen Y, Zhu X* (2010). Live Show of Rho GTPases in Cell 转会. J Mol Cell Biol. 2: 68–69.
  18. Zhu X* (2010). Seeing the Yin and Yang in Cell 生物。 Mol Biol Cell. 21: 3827–3828.
  19. Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposing effects of Ndel1 and α1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1. J Cell Sci. 122, 2820-2827.
  20. Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated 使欣喜若狂。 Traffic. 10:1337-1349.
  21. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin。 PLoS Biol. 7(5): e1000116.
  22. Ma L, Tsai 我, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y* (2009). Requirement for Nudel and dynein for assembly of the lamin B spindle 矩阵. Nat Cell Biol. 11: 247-256.
  23. Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating 细胞. Dev Cell. 14, 342-353.
  24. Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous 小管。 Exp Cell Res. 314, 213-226.
  25. Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome 外国人。 Cell Res. 17, 701-712.
  26. Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M 相。 Mol Biol Cell. 18, 2656-2666.
  27. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent 提取岩芯体 protein 拆卸。 Mol Biol Cell. 17:680-9.
  28. Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell 亡故。 Mol Cell Biol. 25, 4062-74.
  29. Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, 荆 N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription 决定因素的-4。 J Biol Chem . 280, 13973-7.
  30. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic 动力蛋白。 J Cell Biol. 164, 557-566.
  31. Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward 使欣喜若狂。 Cell Res. 13, 275-283.
  32. Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel 蛋白质. FEBS Lett. 540, 77-80.
  33. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic 主轴. Mol Cell Biol. 23, 1239-50.
  34. Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the 枢纽。 Biochem Biophy Res Commun. 280, 513-517.
  35. Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem J. 345, 749-757.
  36. Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M 相。 Mol Cell Biol. 19, 1016-1024.
  37. Zhu X*, Ding L, and Pei G (1997). Carboxyl terminus of mitosin is sufficient to confer spindle pole 状态。 J Cell Biochem. 66:441-449.

研究组分子